Phenanthrenes and derivatives
Medchemexpress LLC Alvespimycin (hydrochloride) | 467214-21-7 | 98.8% | 653.21 | 200 MG
Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM. It inhibits the growth of human cancer cell lines SKBR3 and SKOV3, which overexpress Hsp90 client protein Her2, leading to down-regulation of Her2 and induction of Hsp70. It also induces dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells.
- Potent inhibitor of Hsp90
- Binds to Hsp90 with an EC50 of 62 ± 29 nM
- Inhibits the growth of human cancer cell lines SKBR3 and SKOV3
- Causes down-regulation of Her2
- Induces Hsp70
- Induces dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells
- Significant reduction in tumor size in animal models
Apexbio Technology LLC Kojic acid 501-30-4 200mg
Kojic acid (CAS 501-30-4) is a small-molecule inhibitor targeting tyrosinase a key enzyme involved in melanin biosynthesis It is designed to inhibit tyrosinase activity thereby reducing melanin production Kojic acid exerts its biological activity primarily through chelation of copper ions at the active site of tyrosinase In enzymatic assays on mushroom tyrosinase kojic acid demonstrates inhibitory activity with an IC50 typically ranging from 14 to 50 M Based on these pharmacological properties kojic acid holds research potential in hyperpigmentation disorders skin whitening applications and oxidative stress-related experimental models
Apexbio Technology LLC Oxaloacetic acid 328-42-7 200mg
Oxaloacetic acid (CAS 328-42-7) is a small molecule metabolic intermediate involved in multiple biosynthetic pathways including the citric acid cycle It modulates mitochondrial metabolism and has been shown to reduce intracellular reactive oxygen species (ROS) levels thereby attenuating oxidative stress in cells Due to these properties oxaloacetic acid serves as a valuable tool in the investigation of metabolic disorders and mitochondrial dysfunction in biomedical research
Medchemexpress LLC PROTAC BCR-ABL Degrader-1 | C43H40N10O6 | 25 MG
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1) is a PROTAC with a 2-oxoethyl linker. It induces Bcr-Abl degradation in a ubiquitinproteasome-dependent manner and exhibits antiproliferative activity against K562 cells. It has the potential to study cancer.
- Induces Bcr-Abl degradation.
- Exhibits antiproliferative activity against K562 cells.
- Useful for cancer research.
- Features a 2-oxoethyl linker.
Medchemexpress LLC Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro- | 313-67-7 | 341.27 | 1 ML
Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro- | 313-67-7 | 341.27 | 1 ML
Medchemexpress LLC 2H-1-benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-(3R,4S) | 1213777-80-0 | 99.9% | 348.39 g/mol | C22H20O4 | 5 MG
Triphen diol is a phenol diol small-molecule research compound (CAS 1213777-80-0) reported to induce apoptosis and inhibit proliferation in pancreatic cancer models. It has molecular formula C22H20O4, molecular weight 348.39 g/mol, and is supplied with high reported purity for use in in vitro and in vivo studies. Solubility and storage guidance is provided to support experimental workflows.
- Phenol diol small-molecule with reported anticancer activity.
- Demonstrated apoptosis induction and antiproliferative effects in pancreatic cancer cell lines.
- High reported purity suitable for biological assays.
- Soluble in DMSO at concentrations useful for stock preparations.
- Reported in vivo formulation options that yield clear solutions at ≥2.5 mg/mL.
- Storage recommendations provided to maintain stability during short- and long-term storage.
Cayman Chemical ArIstolochIc AcId C 10mg
An alkaloid; inhibits the growth of LLC-PK1, P388, HT-29, and HL-60 cancer cells (IC50s = 85, 8.8, 17.1, and 40 µM, respectively)
Cayman Chemical ArIstolochIc AcId B 10mg
An alkaloid with mutagenic activity; forms DNA adducts under anaerobic conditions in vitro at 0.4 mM; oral administration induces bladder, forestomach, and kidney DNA adduct formation in rats at 0.03 mmol/kg; reduces body weight and urine concentrations of sodium, potassium, and calcium, enlarges the liver and kidneys, and increases blood concentrations of hemoglobin and hematocrit in rats
Apexbio Technology LLC Alendronic acid 66376-36-1 200mg
Alendronic acid is a small-molecule inhibitor targeting farnesyl diphosphate synthase (FDPS) It is designed to inhibit FDPS activity thereby disrupting protein prenylation pathways required for osteoclast functionality and regulating osteoclast-mediated bone resorption Alendronic acid exerts its biological activity primarily through inhibition of FDPS which suppresses osteoclast activity and associated bone mineral degradation Based on these pharmacological properties alendronic acid holds research potential in the investigation of bone remodeling mechanisms particularly in the contexts of postmenopausal osteoporosis Paget s disease and tumor-related hypercalcemia
eMolecules 2-Aminochrysene | 789-47-9 | MFCD00046286 | 1g
Combi-Blocks, Inc. | 2-Aminochrysene | 1g | 569291100 | HA-4398 | 95.000 | 789-47-9 | MFCD00046286 | 243.309 | C18H13N
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Medchemexpress LLC Chrysen-6-amine | 2642-98-0 | MFCD00003699 | 99.7% | 243.30 g/mol | C18H13N | 10 MG
6-Aminochrysene (chrysen-6-amine) is an aromatic amine research compound supplied in solid and solution formats for biochemical and pharmacological studies. The compound has documented analytical data including purity, molecular formula, and molecular weight, and includes guidance for solubility and storage for laboratory use. Handle and store according to safety data recommendations.